B-Raf V600e Gene Mutation Detection Kit (Real-time PCR)

• Type: IVD Reagent
• Purpose: B-Raf V600e
• Transport Package: Carton Box
• Specification: 50 tests/kit
• Trademark: ultrassay
• Origin: China
• Model NO.: UP-TBRAR24
• HS Code: 3822009020
• Production Capacity: 50000000PCS/Year

Product Description

B-raf V600E Gene Mutation Detection Kit (Real-time PCR)

--Auxiliary diagnostic indicators (DNA) for the individualized treatment plan for cancer patients

[Purpose]

Ultrassay B-raf V600E Gene Mutation RT PCR test kit is used for the detection of mutations in tumor-specific oncogene gene B-raf V600E, and can be used for individualized molecular diagnosis of tumors, thereby guiding individualized clinical treatment plans for tumor patients.

Mutation Frequency of B-raf Gene V600E:

• 60%~80% Malignant Melanoma
• 29%~83% Thyroid Cancer
• 6%~15% Colorectal Cancer
• 1 % ~3 % Lung Cancer

[Advantage]

• High Sensitivity: Accurate detection of B-raf gene V600E site mutation as
  low as 1%;
• Strong Specificity: Dual blocking technology by using ARMS primers and blocking probes, effectively increasing the specificity of detection;
• Easy Operation: Completing the test within 3 hours from submiting the
  specimen to geting the result;
• High Accuracy: Reliable results and reducing false negative test results through internal control gene supervision.

[Clinical Significance]

• Medication Guide 1: Patients with wild-type K-ras gene and mutations in B-raf gene show ineffective treatment with EGFR inhibitors such as cetuximab and panitumumab
• Medication Guide 2: Panitumumab and Erbitux have significant curative effect in patients with wild-type tumors of B-raf gene
• Prognostic Indicators:
  B-raf mutation is not only a predictive indicator, but also a prognostic indicator. The colorectal cancer patients with B-raf mutation has a poor prognosis.

Packing Specifications: 12 Tests/Kit
Testing Samples: Tumor patient's lesion tissue (papillary thyroid cancer, malignant melanoma, colorectal cancer, lung cancer), including fresh diseased tissue, frozen pathological section, paraffin-embedded pathological tissue or section.