Mthfr Gene Polymorphism Detection Kit Arms PCR

• Customization: Available
• Type: IVD Reagent
• Intended Use: Homocysteine Level Abnormal Folic Acid Metabolism
• Model NO.: MTHFR
• Certificate: CE
• Transport Package: Carton Box
• Specification: 48 tests/kit
• Trademark: ultrassay
• Origin: China
• HS Code: 3822009020
• Production Capacity: 500000tests/Month

Product Description

[Intended use]
This kit is used for the qualitative detection of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism at c.677 site in human peripheral blood samples in patients with high homocysteine level or abnormal folic acid metabolism Provide auxiliary diagnosis.
5'10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methionine-folate metabolism system, involved in maintaining the normal metabolism of folic acid and maintaining normal homocysteine levels in the body. The polymorphism of the c.677 site of the MTHFR gene can lead to a decrease in the activity of the key enzyme encoding folic acid metabolism, leading to folic acid metabolism disorder, resulting in decreased folic acid level and hyperhomocysteinemia. For people with MTHFR gene abnormality, the enzyme activity is significantly reduced, resulting in folic acid metabolism disorder, "one-carbon group" metabolism abnormality, resulting in a significantly increased risk of Down syndrome, neonatal neural tube defects and other diseases, such people need supplementation More folic acid is needed to achieve the desired effect. The distribution frequency of the c.677 (C/T) site of the MTHFR gene in the Chinese population is shown in the table below.

Gene	Site	Genotype	The proportion of genotypes in the Chinese population
MTHFR	c.677	CC;CT;TT Normal Normal Risk	29.1%;48.5%;22.3%

The test results of this kit are only for clinicians to provide reference for homocysteine metabolism. It is suitable for clinical auxiliary diagnosis, and should be judged based on the actual situation of the case, rather than the only standard for clinical diagnosis